Detalhe da pesquisa
1.
Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate.
Proc Natl Acad Sci U S A
; 119(11): e2112008119, 2022 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35263223
2.
Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer.
Proc Natl Acad Sci U S A
; 118(3)2021 01 19.
Artigo
Inglês
| MEDLINE | ID: mdl-33431677
3.
Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization.
J Virol
; 94(22)2020 10 27.
Artigo
Inglês
| MEDLINE | ID: mdl-32878891
4.
Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design.
PLoS Pathog
; 15(5): e1007772, 2019 05.
Artigo
Inglês
| MEDLINE | ID: mdl-31100098
5.
Antigenicity and Immunogenicity of Differentially Glycosylated Hepatitis C Virus E2 Envelope Proteins Expressed in Mammalian and Insect Cells.
J Virol
; 93(7)2019 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30651366
6.
Interferon-Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection.
Hepatology
; 70(5): 1506-1520, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31062385
7.
Global mapping of antibody recognition of the hepatitis C virus E2 glycoprotein: Implications for vaccine design.
Proc Natl Acad Sci U S A
; 113(45): E6946-E6954, 2016 Nov 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27791171
8.
Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus.
J Virol
; 90(6): 3112-22, 2016 Jan 06.
Artigo
Inglês
| MEDLINE | ID: mdl-26739044
9.
Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus Glycoprotein.
J Virol
; 90(1): 279-91, 2016 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26468532
10.
Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice.
Hepatology
; 64(6): 1922-1933, 2016 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27641232
11.
Structural basis for penetration of the glycan shield of hepatitis C virus E2 glycoprotein by a broadly neutralizing human antibody.
J Biol Chem
; 290(16): 10117-25, 2015 Apr 17.
Artigo
Inglês
| MEDLINE | ID: mdl-25737449
12.
An anti-H5N1 influenza virus FcDART antibody is a highly efficacious therapeutic agent and prophylactic against H5N1 influenza virus infection.
J Virol
; 89(8): 4549-61, 2015 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-25673719
13.
Non-random escape pathways from a broadly neutralizing human monoclonal antibody map to a highly conserved region on the hepatitis C virus E2 glycoprotein encompassing amino acids 412-423.
PLoS Pathog
; 10(8): e1004297, 2014 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-25122476
14.
Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape.
PLoS Pathog
; 9(5): e1003364, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23696737
15.
Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a.
Hepatology
; 60(5): 1551-62, 2014 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-25043937
16.
Learning from a clinical cohort for HCV vaccine development.
J Hepatol
; 71(1): 9-11, 2019 07.
Artigo
Inglês
| MEDLINE | ID: mdl-30992137
17.
Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate.
PLoS Pathog
; 8(4): e1002653, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22511875
18.
Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.
Gastroenterology
; 143(1): 223-233.e9, 2012 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-22503792
19.
Toward a hepatitis C virus vaccine: the structural basis of hepatitis C virus neutralization by AP33, a broadly neutralizing antibody.
J Virol
; 86(23): 12923-32, 2012 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-22993159
20.
Affinity maturation to improve human monoclonal antibody neutralization potency and breadth against hepatitis C virus.
J Biol Chem
; 286(51): 44218-44233, 2011 Dec 23.
Artigo
Inglês
| MEDLINE | ID: mdl-22002064